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They have very different evidence bases and risk profiles
Phase 3 trials include a 4mg maintenance arm specifically because some individuals achieve excellent results at lower doses
Hashimoto Y, Niikura T, Tajima H, Yasukawa T, Sudo H, Ito Y, Kita Y, Kawasumi M, Kouyama K, Doyu M, Sobue G, Koide T, Tsuji S, Lang J, Kurokawa K, Nishimoto I
High-dose prescribing by default Many vendors escalate members to the maximum dose, regardless of need
Healthier food choices made during the adjustment period often become permanent habits
Toxic overload and depression may become linked when exposure exceeds antioxidant, methylation and clearance capacity
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